It has taken 10 years, two little Fockers with wife Pam and countless hurdles for Greg to finally get "in" with his tightly wound father-in-law Jack. After the cash-strapped Dad takes a job moonlighting for a drug company, Jack's suspicions about his favorite male nurse come roaring back.

When Greg and Pam's entire clan descends for the twins birthday party, Greg must prove to Jack that he is capable of being the man of the house.