The Emishi people are under attack from a demon boar god. Its prince, Ashitaka, is compelled to save his home. Though he succeeds, a deadly curse is implanted upon him. Knowing his fate, he leaves his village on a journey for answers. He comes upon Irontown where the ambitious Lady Eboshi resides. His life is entwined with a mysterious girl named San and eventually, the battle between nature and civilization will unfold.