Gru, supervillain-turned-Anti-Villain League-agent, returns for a new era of Minions mayhem, alongside his wife and fellow Anti-Villain League-agent Lucy, their three adopted girls—Margo, Edith and Agnes—and the newest member to the Gru family, Gru Jr., who is intent on tormenting his dad. The family is forced to go on the run when they become targeted by escaped criminal Maxime Le Mal and his femme fatale girlfriend Valentina.